5U2D

Crystal Structure of the ER-alpha Ligand-binding Domain (Y537S) in complex with Oxabicyclic Heptene Sulfonate (OBHS)

Summary for 5U2D

• Entry DOI: 10.2210/pdb5u2d/pdb
• Related: 5U2B
• Descriptor: Estrogen receptor, Nuclear receptor coactivator 2, cyclohexa-2,5-dien-1-yl (1S,2R,4S)-5,6-bis(4-hydroxyphenyl)-7-oxabicyclo[2.2.1]hept-5-ene-2-sulfonate, ... (4 entities in total)
• Functional Keywords: protein ligand complex, transcription
• Biological source: Homo sapiens (Human); More
• Cellular location: Isoform 1: Nucleus . Isoform 3: Nucleus. Nucleus: P03372; Nucleus: Q15596
• Total number of polymer chains: 4
• Total formula weight: 62635.79

Authors

Nwachukwu, J.C.,Erumbi, R.,Nowak, J.,Carlson, K.E.,Katzenellenbogen, J.A.,Izard, T.,Nettles, K.W. (deposition date: 2016-11-30, release date: 2017-04-05, Last modification date: 2024-03-06)

• Primary citation: Stender, J.D.,Nwachukwu, J.C.,Kastrati, I.,Kim, Y.,Strid, T.,Yakir, M.,Srinivasan, S.,Nowak, J.,Izard, T.,Rangarajan, E.S.,Carlson, K.E.,Katzenellenbogen, J.A.,Yao, X.Q.,Grant, B.J.,Leong, H.S.,Lin, C.Y.,Frasor, J.,Nettles, K.W.,Glass, C.K.; Structural and Molecular Mechanisms of Cytokine-Mediated Endocrine Resistance in Human Breast Cancer Cells.; Mol. Cell, 65:1122-1135.e5, 2017; PubMed: 28306507; DOI: 10.1016/j.molcel.2017.02.008

Experimental method

X-RAY DIFFRACTION (1.86 Å)