5T3S

HIV gp140 trimer MD39-10MUTA in complex with Fabs PGT124 and 35022

Summary for 5T3S

• Entry DOI: 10.2210/pdb5t3s/pdb
• Descriptor: Envelope glycoprotein gp160, alpha-D-mannopyranose-(1-3)-beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, alpha-D-mannopyranose-(1-3)-[alpha-D-mannopyranose-(1-6)]alpha-D-mannopyranose-(1-6)-[alpha-D-mannopyranose-(1-3)]beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ... (13 entities in total)
• Functional Keywords: hiv-1 neutralizing antibody, immune system
• Biological source: Human immunodeficiency virus 1; More
• Total number of polymer chains: 6
• Total formula weight: 178750.85

Authors

Stanfield, R.L.,Wilson, I.A. (deposition date: 2016-08-26, release date: 2016-09-28, Last modification date: 2023-10-04)

• Primary citation: Steichen, J.M.,Kulp, D.W.,Tokatlian, T.,Escolano, A.,Dosenovic, P.,Stanfield, R.L.,McCoy, L.E.,Ozorowski, G.,Hu, X.,Kalyuzhniy, O.,Briney, B.,Schiffner, T.,Garces, F.,Freund, N.T.,Gitlin, A.D.,Menis, S.,Georgeson, E.,Kubitz, M.,Adachi, Y.,Jones, M.,Mutafyan, A.A.,Yun, D.S.,Mayer, C.T.,Ward, A.B.,Burton, D.R.,Wilson, I.A.,Irvine, D.J.,Nussenzweig, M.C.,Schief, W.R.; HIV Vaccine Design to Target Germline Precursors of Glycan-Dependent Broadly Neutralizing Antibodies.; Immunity, 45:483-496, 2016; PubMed: 27617678; DOI: 10.1016/j.immuni.2016.08.016

Experimental method

X-RAY DIFFRACTION (4.5 Å)