5OY4
GSK3beta complex with N-(6-(3,4-dihydroxyphenyl)-1H-pyrazolo[3,4-b]pyridin-3-yl)acetamide
Summary for 5OY4
Entry DOI | 10.2210/pdb5oy4/pdb |
Descriptor | Glycogen synthase kinase-3 beta, Proto-oncogene FRAT1, SULFATE ION, ... (5 entities in total) |
Functional Keywords | phosphoinositide-3-kinase delta inhibitor, pi3k delta inhibitor, kinase cross-screening, transferase |
Biological source | Homo sapiens (Human) More |
Cellular location | Cytoplasm : P49841 Q92837 |
Total number of polymer chains | 4 |
Total formula weight | 152975.12 |
Authors | Bax, B.D.,Convery, M.A. (deposition date: 2017-09-07, release date: 2017-11-01, Last modification date: 2024-01-17) |
Primary citation | Henley, Z.A.,Bax, B.D.,Inglesby, L.M.,Champigny, A.,Gaines, S.,Faulder, P.,Le, J.,Thomas, D.A.,Washio, Y.,Baldwin, I.R. From PIM1 to PI3K delta via GSK3 beta : Target Hopping through the Kinome. ACS Med Chem Lett, 8:1093-1098, 2017 Cited by PubMed: 29057057DOI: 10.1021/acsmedchemlett.7b00296 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (3.2 Å) |
Structure validation
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