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5OY4

GSK3beta complex with N-(6-(3,4-dihydroxyphenyl)-1H-pyrazolo[3,4-b]pyridin-3-yl)acetamide

Summary for 5OY4
Entry DOI10.2210/pdb5oy4/pdb
DescriptorGlycogen synthase kinase-3 beta, Proto-oncogene FRAT1, SULFATE ION, ... (5 entities in total)
Functional Keywordsphosphoinositide-3-kinase delta inhibitor, pi3k delta inhibitor, kinase cross-screening, transferase
Biological sourceHomo sapiens (Human)
More
Cellular locationCytoplasm : P49841 Q92837
Total number of polymer chains4
Total formula weight152975.12
Authors
Bax, B.D.,Convery, M.A. (deposition date: 2017-09-07, release date: 2017-11-01, Last modification date: 2024-01-17)
Primary citationHenley, Z.A.,Bax, B.D.,Inglesby, L.M.,Champigny, A.,Gaines, S.,Faulder, P.,Le, J.,Thomas, D.A.,Washio, Y.,Baldwin, I.R.
From PIM1 to PI3K delta via GSK3 beta : Target Hopping through the Kinome.
ACS Med Chem Lett, 8:1093-1098, 2017
Cited by
PubMed: 29057057
DOI: 10.1021/acsmedchemlett.7b00296
PDB entries with the same primary citation
Experimental method
X-RAY DIFFRACTION (3.2 Å)
Structure validation

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