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5NRW

Crystal structure of the human bromodomain of CREBBP bound to the inhibitor XDM4

Summary for 5NRW
Entry DOI10.2210/pdb5nrw/pdb
DescriptorCREB-binding protein, 4-ethanoyl-3-ethyl-5-methyl-~{N}-(naphthalen-1-ylmethyl)-1~{H}-pyrrole-2-carboxamide, 1,2-ETHANEDIOL, ... (4 entities in total)
Functional Keywordsbromodomain, protein-inhibitor complex, cbp, epigenetics, transcription
Biological sourceHomo sapiens (Human)
Cellular locationCytoplasm: Q92793
Total number of polymer chains1
Total formula weight14806.03
Authors
Huegle, M.,Wohlwend, D. (deposition date: 2017-04-25, release date: 2017-08-16, Last modification date: 2024-01-17)
Primary citationHugle, M.,Lucas, X.,Ostrovskyi, D.,Regenass, P.,Gerhardt, S.,Einsle, O.,Hau, M.,Jung, M.,Breit, B.,Gunther, S.,Wohlwend, D.
Beyond the BET Family: Targeting CBP/p300 with 4-Acyl Pyrroles.
Angew. Chem. Int. Ed. Engl., 56:12476-12480, 2017
Cited by
PubMed: 28766825
DOI: 10.1002/anie.201705516
PDB entries with the same primary citation
Experimental method
X-RAY DIFFRACTION (1.7 Å)
Structure validation

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