5NRW
Crystal structure of the human bromodomain of CREBBP bound to the inhibitor XDM4
Summary for 5NRW
Entry DOI | 10.2210/pdb5nrw/pdb |
Descriptor | CREB-binding protein, 4-ethanoyl-3-ethyl-5-methyl-~{N}-(naphthalen-1-ylmethyl)-1~{H}-pyrrole-2-carboxamide, 1,2-ETHANEDIOL, ... (4 entities in total) |
Functional Keywords | bromodomain, protein-inhibitor complex, cbp, epigenetics, transcription |
Biological source | Homo sapiens (Human) |
Cellular location | Cytoplasm: Q92793 |
Total number of polymer chains | 1 |
Total formula weight | 14806.03 |
Authors | Huegle, M.,Wohlwend, D. (deposition date: 2017-04-25, release date: 2017-08-16, Last modification date: 2024-01-17) |
Primary citation | Hugle, M.,Lucas, X.,Ostrovskyi, D.,Regenass, P.,Gerhardt, S.,Einsle, O.,Hau, M.,Jung, M.,Breit, B.,Gunther, S.,Wohlwend, D. Beyond the BET Family: Targeting CBP/p300 with 4-Acyl Pyrroles. Angew. Chem. Int. Ed. Engl., 56:12476-12480, 2017 Cited by PubMed: 28766825DOI: 10.1002/anie.201705516 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.7 Å) |
Structure validation
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