5MW6

Crystal structure of the BCL6 BTB-domain with compound 1

Summary for 5MW6

Entry DOI	10.2210/pdb5mw6/pdb
Descriptor	B-cell lymphoma 6 protein, 5-chloranyl-~{N}-(4-chlorophenyl)-2-(3,5-dimethylpyrazol-1-yl)pyrimidin-4-amine (3 entities in total)
Functional Keywords	transcription, inhibitor
Biological source	Homo sapiens (Human)
Cellular location	Nucleus : P41182
Total number of polymer chains	2
Total formula weight	29673.95
Authors	Davies, D.R.,Kessler, D. (deposition date: 2017-01-18, release date: 2017-10-04, Last modification date: 2017-10-11)
Primary citation	Kerres, N.,Steurer, S.,Schlager, S.,Bader, G.,Berger, H.,Caligiuri, M.,Dank, C.,Engen, J.R.,Ettmayer, P.,Fischerauer, B.,Flotzinger, G.,Gerlach, D.,Gerstberger, T.,Gmaschitz, T.,Greb, P.,Han, B.,Heyes, E.,Iacob, R.E.,Kessler, D.,Kolle, H.,Lamarre, L.,Lancia, D.R.,Lucas, S.,Mayer, M.,Mayr, K.,Mischerikow, N.,Muck, K.,Peinsipp, C.,Petermann, O.,Reiser, U.,Rudolph, D.,Rumpel, K.,Salomon, C.,Scharn, D.,Schnitzer, R.,Schrenk, A.,Schweifer, N.,Thompson, D.,Traxler, E.,Varecka, R.,Voss, T.,Weiss-Puxbaum, A.,Winkler, S.,Zheng, X.,Zoephel, A.,Kraut, N.,McConnell, D.,Pearson, M.,Koegl, M. Chemically Induced Degradation of the Oncogenic Transcription Factor BCL6. Cell Rep, 20:2860-2875, 2017 Cited by PubMed: 28930682 DOI: 10.1016/j.celrep.2017.08.081 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.65 Å)

Structure validation