5MPZ
Crystal structure of CREBBP bromodomain complexed with CBP007
Summary for 5MPZ
| Entry DOI | 10.2210/pdb5mpz/pdb |
| Descriptor | CREB-binding protein, methyl 2-oxidanylidene-3~{H}-1,3-benzoxazole-6-carboxylate (3 entities in total) |
| Functional Keywords | crebbp bromodomain, inhibitor, transcription |
| Biological source | Homo sapiens (Human) |
| Total number of polymer chains | 1 |
| Total formula weight | 14609.66 |
| Authors | Zhu, J.,Spiliotopoulos, D.,Caflisch, A. (deposition date: 2016-12-19, release date: 2017-05-10, Last modification date: 2019-10-16) |
| Primary citation | Spiliotopoulos, D.,Zhu, J.,Wamhoff, E.C.,Deerain, N.,Marchand, J.R.,Aretz, J.,Rademacher, C.,Caflisch, A. Virtual screen to NMR (VS2NMR): Discovery of fragment hits for the CBP bromodomain. Bioorg. Med. Chem. Lett., 27:2472-2478, 2017 Cited by PubMed: 28410781DOI: 10.1016/j.bmcl.2017.04.001 PDB entries with the same primary citation |
| Experimental method | X-RAY DIFFRACTION (1.4 Å) |
Structure validation
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