5M70
Crystal Structure of human RhoGAP mutated in its arginin finger (R85A) in complex with RhoA.GDP.AlF4- human
Summary for 5M70
Entry DOI | 10.2210/pdb5m70/pdb |
Descriptor | Rho GTPase-activating protein 1, Transforming protein RhoA, MAGNESIUM ION, ... (6 entities in total) |
Functional Keywords | rhogap, arginine finger, rhoa, transition state, signaling protein |
Biological source | Homo sapiens (Human) More |
Cellular location | Cytoplasm: Q07960 Cell membrane; Lipid-anchor; Cytoplasmic side: P61586 |
Total number of polymer chains | 4 |
Total formula weight | 98787.04 |
Authors | Pellegrini, E.,Bowler, M.W. (deposition date: 2016-10-26, release date: 2017-05-17, Last modification date: 2024-01-17) |
Primary citation | Jin, Y.,Molt, R.W.,Pellegrini, E.,Cliff, M.J.,Bowler, M.W.,Richards, N.G.J.,Blackburn, G.M.,Waltho, J.P. Assessing the Influence of Mutation on GTPase Transition States by Using X-ray Crystallography, (19) F NMR, and DFT Approaches. Angew. Chem. Int. Ed. Engl., 56:9732-9735, 2017 Cited by PubMed: 28498638DOI: 10.1002/anie.201703074 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.2 Å) |
Structure validation
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