5LVL
Human PDK1 Kinase Domain in Complex with Compound PS653 Bound to the ATP-Binding Site
Summary for 5LVL
Entry DOI | 10.2210/pdb5lvl/pdb |
Descriptor | 3-phosphoinositide-dependent protein kinase 1, 2,6-DIHYDROANTHRA/1,9-CD/PYRAZOL-6-ONE, DITHIANE DIOL, ... (5 entities in total) |
Functional Keywords | protein kinase, allosteric regulation, small compounds, pif-pocket, transferase |
Biological source | Homo sapiens (Human) |
Total number of polymer chains | 1 |
Total formula weight | 35999.43 |
Authors | Schulze, J.O.,Saladino, G.,Busschots, K.,Neimanis, S.,Suess, E.,Odadzic, D.,Zeuzem, S.,Hindie, V.,Herbrand, A.K.,Lisa, M.N.,Alzari, P.M.,Gervasio, F.L.,Biondi, R.M. (deposition date: 2016-09-14, release date: 2016-10-19, Last modification date: 2024-01-17) |
Primary citation | Schulze, J.O.,Saladino, G.,Busschots, K.,Neimanis, S.,Su, E.,Odadzic, D.,Zeuzem, S.,Hindie, V.,Herbrand, A.K.,Lisa, M.N.,Alzari, P.M.,Gervasio, F.L.,Biondi, R.M. Bidirectional Allosteric Communication between the ATP-Binding Site and the Regulatory PIF Pocket in PDK1 Protein Kinase. Cell Chem Biol, 23:1193-1205, 2016 Cited by PubMed: 27693059DOI: 10.1016/j.chembiol.2016.06.017 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.4 Å) |
Structure validation
Download full validation report