5LA6
Tubulin-pironetin complex
Summary for 5LA6
Entry DOI | 10.2210/pdb5la6/pdb |
Descriptor | Tubulin alpha-1B chain, PHOSPHOMETHYLPHOSPHONIC ACID ADENYLATE ESTER, Tubulin beta-2B chain, ... (11 entities in total) |
Functional Keywords | cell cycle, tubulin fold, cytoskeleton, microtubule |
Biological source | Rattus norvegicus (Norway Rat) More |
Cellular location | Cytoplasm, cytoskeleton: P81947 Q6B856 Golgi apparatus : P63043 |
Total number of polymer chains | 6 |
Total formula weight | 264628.99 |
Authors | Prota, A.E.,Setter, J.,Waight, A.B.,Bargsten, K.,Murga, J.,Diaz, J.F.,Steinmetz, M.O. (deposition date: 2016-06-13, release date: 2016-07-20, Last modification date: 2024-01-10) |
Primary citation | Prota, A.E.,Setter, J.,Waight, A.B.,Bargsten, K.,Murga, J.,Diaz, J.F.,Steinmetz, M.O. Pironetin Binds Covalently to alpha Cys316 and Perturbs a Major Loop and Helix of alpha-Tubulin to Inhibit Microtubule Formation. J.Mol.Biol., 428:2981-2988, 2016 Cited by PubMed: 27395016DOI: 10.1016/j.jmb.2016.06.023 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.1 Å) |
Structure validation
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