5L7H

MCR IN COMPLEX WITH ligand

Summary for 5L7H

• Entry DOI: 10.2210/pdb5l7h/pdb
• Descriptor: Mineralocorticoid receptor, NCOA1 peptide, 3-methyl-5,8-dioxa-17lambda-thia-4,18-diazatetracyclo[18.2.2.1,.0]pentacosa-1(22),2(6),3,9,11,13(25),20,23-octaene-17,17-dione, ... (5 entities in total)
• Functional Keywords: mineralocorticoid receptor 2, signaling protein
• Biological source: Homo sapiens (Human); More
• Total number of polymer chains: 2
• Total formula weight: 36611.90

Authors

Xue, Y.,Aagaard, A.,Backstrom, S.,Edman, K. (deposition date: 2016-06-03, release date: 2016-12-07, Last modification date: 2019-10-16)

• Primary citation: Nordqvist, A.,O'Mahony, G.,Friden-Saxin, M.,Fredenwall, M.,Hogner, A.,Granberg, K.L.,Aagaard, A.,Backstrom, S.,Gunnarsson, A.,Kaminski, T.,Xue, Y.,Dellsen, A.,Hansson, E.,Hansson, P.,Ivarsson, I.,Karlsson, U.,Bamberg, K.,Hermansson, M.,Georgsson, J.,Lindmark, B.,Edman, K.; Structure-Based Drug Design of Mineralocorticoid Receptor Antagonists to Explore Oxosteroid Receptor Selectivity.; ChemMedChem, 12:50-65, 2017; PubMed: 27897427; DOI: 10.1002/cmdc.201600529

Experimental method

X-RAY DIFFRACTION (1.84 Å)