5KJI

Crystal structure of an active polycomb repressive complex 2 in the basal state

Replaces:  5CH2

Summary for 5KJI

• Entry DOI: 10.2210/pdb5kji/pdb
• Descriptor: putative polycomb protein Eed, Putative uncharacterized protein,Zinc finger domain-containing protein, ZINC ION, ... (5 entities in total)
• Functional Keywords: complex, methyltransferase, transferase
• Biological source: Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719); More
• Total number of polymer chains: 2
• Total formula weight: 173798.65

Authors

Jiao, L.,Liu, X. (deposition date: 2016-06-20, release date: 2017-04-19, Last modification date: 2023-09-27)

Primary citation

Jiao, L.,Liu, X.
Response to Comment on "Structural basis of histone H3K27 trimethylation by an active polycomb repressive complex 2".
Science, 354:1543-1543, 2016

PubMed Abstract: Zhang et al suggested that in the crystal structure of a polycomb repressive complex 2 from Chaetomium thermophilum (ctPRC2), a flexible linker region, but not the H3K27M cancer mutant peptide, better fits the electron density. Based on our new data, we agree with this alternative interpretation and provide the crystal structure of ctPRC2 bound to a bona fide H3K27M sequence.

PubMed: 28008038
DOI: 10.1126/science.aaj2335

Experimental method

X-RAY DIFFRACTION (2.71 Å)