5K4J
Crystal Structure of CDK2 in complex with compound 22
Summary for 5K4J
Entry DOI | 10.2210/pdb5k4j/pdb |
Related | 5K4I |
Descriptor | Cyclin-dependent kinase 2, 1-[(1~{S})-1-(4-chloranyl-3-fluoranyl-phenyl)-2-oxidanyl-ethyl]-4-[2-[(2-methylpyrazol-3-yl)amino]pyrimidin-4-yl]pyridin-2-one (3 entities in total) |
Functional Keywords | protein kinase, transferase-transferase inhibitor complex, transferase/transferase inhibitor |
Biological source | Homo sapiens (Human) |
Cellular location | Cytoplasm, cytoskeleton, microtubule organizing center, centrosome: P24941 |
Total number of polymer chains | 1 |
Total formula weight | 34488.43 |
Authors | |
Primary citation | Blake, J.F.,Burkard, M.,Chan, J.,Chen, H.,Chou, K.J.,Diaz, D.,Dudley, D.A.,Gaudino, J.J.,Gould, S.E.,Grina, J.,Hunsaker, T.,Liu, L.,Martinson, M.,Moreno, D.,Mueller, L.,Orr, C.,Pacheco, P.,Qin, A.,Rasor, K.,Ren, L.,Robarge, K.,Shahidi-Latham, S.,Stults, J.,Sullivan, F.,Wang, W.,Yin, J.,Zhou, A.,Belvin, M.,Merchant, M.,Moffat, J.,Schwarz, J.B. Discovery of (S)-1-(1-(4-Chloro-3-fluorophenyl)-2-hydroxyethyl)-4-(2-((1-methyl-1H-pyrazol-5-yl)amino)pyrimidin-4-yl)pyridin-2(1H)-one (GDC-0994), an Extracellular Signal-Regulated Kinase 1/2 (ERK1/2) Inhibitor in Early Clinical Development. J.Med.Chem., 59:5650-5660, 2016 Cited by PubMed: 27227380DOI: 10.1021/acs.jmedchem.6b00389 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.6 Å) |
Structure validation
Download full validation report