5JQ6
Crystal structure of ClfA in complex with the Fab fragment of Tefibazumab
Summary for 5JQ6
Entry DOI | 10.2210/pdb5jq6/pdb |
Descriptor | Clumping factor A, Tefibazumab FAB FRAGMENT HEAVY CHAIN, Tefibazumab FAB FRAGMENT LIGHT CHAIN, ... (4 entities in total) |
Functional Keywords | staphylococcal infections, clumping factor a, fibrinogen, tefibazumab, aurexis, mscramm, immune system |
Biological source | Staphylococcus aureus More |
Total number of polymer chains | 3 |
Total formula weight | 83295.59 |
Authors | Ganesh, V.K. (deposition date: 2016-05-04, release date: 2017-01-18, Last modification date: 2023-09-27) |
Primary citation | Ganesh, V.K.,Liang, X.,Geoghegan, J.A.,Cohen, A.L.,Venugopalan, N.,Foster, T.J.,Hook, M. Lessons from the Crystal Structure of the S. aureus Surface Protein Clumping Factor A in Complex With Tefibazumab, an Inhibiting Monoclonal Antibody. EBioMedicine, 13:328-338, 2016 Cited by PubMed: 27789272DOI: 10.1016/j.ebiom.2016.09.027 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.4 Å) |
Structure validation
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