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5JO0

Structure of Plasmodium falciparum DXR in complex with a beta-substituted fosmidomycin analogue, LC56 and manganese

Summary for 5JO0
Entry DOI10.2210/pdb5jo0/pdb
Descriptor1-deoxy-D-xylulose 5-phosphate reductoisomerase, apicoplastic, [(2R)-2-{2-[hydroxy(methyl)amino]-2-oxoethyl}-5-(3-methylphenyl)pentyl]phosphonic acid, MANGANESE (II) ION, ... (7 entities in total)
Functional Keywordsenzyme-inhibitor complex, mep pathway, isoprenoid biosynthesis, oxidoreductase
Biological sourcePlasmodium falciparum 3D7
Cellular locationPlastid, apicoplast : Q8IKG4
Total number of polymer chains2
Total formula weight98049.53
Authors
Sooriyaarachchi, S.,Bergfors, T.,Jones, T.A.,Mowbray, S.L. (deposition date: 2016-05-01, release date: 2016-08-24, Last modification date: 2024-01-10)
Primary citationSooriyaarachchi, S.,Chofor, R.,Risseeuw, M.D.,Bergfors, T.,Pouyez, J.,Dowd, C.S.,Maes, L.,Wouters, J.,Jones, T.A.,Van Calenbergh, S.,Mowbray, S.L.
Targeting an Aromatic Hotspot in Plasmodium falciparum 1-Deoxy-d-xylulose-5-phosphate Reductoisomerase with beta-Arylpropyl Analogues of Fosmidomycin.
Chemmedchem, 11:2024-2036, 2016
Cited by
PubMed: 27487410
DOI: 10.1002/cmdc.201600249
PDB entries with the same primary citation
Experimental method
X-RAY DIFFRACTION (1.8 Å)
Structure validation

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