Loading
PDBj
MenuPDBj@FacebookPDBj@TwitterPDBj@YouTubewwPDB FoundationwwPDB
RCSB PDBPDBeBMRBAdv. SearchSearch help

5IGK

Crystal structure of the first bromodomain of human BRD4 in complex with bromosporine (BSP)

Summary for 5IGK
Entry DOI10.2210/pdb5igk/pdb
DescriptorBromodomain-containing protein 4, 1,2-ETHANEDIOL, Bromosporine, ... (4 entities in total)
Functional Keywordstranscription, post translational modifications, bet family, structural genomics, structural genomics consortium, sgc
Biological sourceHomo sapiens (Human)
Cellular locationNucleus: O60885
Total number of polymer chains1
Total formula weight15565.89
Authors
Filippakopoulos, P.,Picaud, S.,Felletar, I.,von Delft, F.,Edwards, A.M.,Arrowsmith, C.H.,Bountra, C.,Knapp, S.,Structural Genomics Consortium (SGC) (deposition date: 2016-02-28, release date: 2016-10-19, Last modification date: 2024-01-10)
Primary citationPicaud, S.,Leonards, K.,Lambert, J.P.,Dovey, O.,Wells, C.,Fedorov, O.,Monteiro, O.,Fujisawa, T.,Wang, C.Y.,Lingard, H.,Tallant, C.,Nikbin, N.,Guetzoyan, L.,Ingham, R.,Ley, S.V.,Brennan, P.,Muller, S.,Samsonova, A.,Gingras, A.C.,Schwaller, J.,Vassiliou, G.,Knapp, S.,Filippakopoulos, P.
Promiscuous targeting of bromodomains by bromosporine identifies BET proteins as master regulators of primary transcription response in leukemia.
Sci Adv, 2:e1600760-e1600760, 2016
Cited by
PubMed: 27757418
DOI: 10.1126/sciadv.1600760
PDB entries with the same primary citation
Experimental method
X-RAY DIFFRACTION (1.7 Å)
Structure validation

217705

PDB entries from 2024-03-27

PDB statisticsPDBj update infoContact PDBjnumon