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5HYN

Structure of Human Polycomb Repressive Complex 2 (PRC2) with oncogenic histone H3K27M peptide

Summary for 5HYN
Entry DOI10.2210/pdb5hyn/pdb
DescriptorHistone-lysine N-methyltransferase EZH2, Polycomb protein EED, Polycomb protein SUZ12, ... (7 entities in total)
Functional Keywordschromatin modification complex, transferase
Biological sourceHomo sapiens (Human)
More
Cellular locationNucleus : Q15910 O75530 Q15022
Total number of polymer chains20
Total formula weight586815.22
Authors
Zhang, Y.,Justin, N.,Wilson, J.R.,Gamblin, S.J. (deposition date: 2016-02-01, release date: 2016-05-11)
Primary citationJustin, N.,Zhang, Y.,Tarricone, C.,Martin, S.R.,Chen, S.,Underwood, E.,De Marco, V.,Haire, L.F.,Walker, P.A.,Reinberg, D.,Wilson, J.R.,Gamblin, S.J.
Structural basis of oncogenic histone H3K27M inhibition of human polycomb repressive complex 2.
Nat Commun, 7:11316-11316, 2016
Cited by
PubMed: 27121947
DOI: 10.1038/ncomms11316
PDB entries with the same primary citation
Experimental method
X-RAY DIFFRACTION (2.95 Å)
Structure validation

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