5HXB
Cereblon in complex with DDB1, CC-885, and GSPT1
Summary for 5HXB
Entry DOI | 10.2210/pdb5hxb/pdb |
Descriptor | Eukaryotic peptide chain release factor GTP-binding subunit ERF3A, DNA damage-binding protein 1, Protein cereblon, ... (5 entities in total) |
Functional Keywords | e3, ligase, ubiquitin, dcaf, cereblon, ddb1, crl4, cullin, imid, gspt1, crbn |
Biological source | Homo sapiens (Human) More |
Cellular location | Cytoplasm: Q16531 Q96SW2 |
Total number of polymer chains | 6 |
Total formula weight | 392392.25 |
Authors | Chamberlain, P.P.,Matyskiela, M.,Pagarigan, B. (deposition date: 2016-01-30, release date: 2016-06-29, Last modification date: 2023-09-27) |
Primary citation | Matyskiela, M.E.,Lu, G.,Ito, T.,Pagarigan, B.,Lu, C.C.,Miller, K.,Fang, W.,Wang, N.Y.,Nguyen, D.,Houston, J.,Carmel, G.,Tran, T.,Riley, M.,Nosaka, L.,Lander, G.C.,Gaidarova, S.,Xu, S.,Ruchelman, A.L.,Handa, H.,Carmichael, J.,Daniel, T.O.,Cathers, B.E.,Lopez-Girona, A.,Chamberlain, P.P. A novel cereblon modulator recruits GSPT1 to the CRL4(CRBN) ubiquitin ligase. Nature, 535:252-257, 2016 Cited by PubMed: 27338790DOI: 10.1038/nature18611 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (3.6 Å) |
Structure validation
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