5HLP
X-RAY CRYSTAL STRUCTURE OF GSK3B IN COMPLEX WITH BRD3937
Summary for 5HLP
Entry DOI | 10.2210/pdb5hlp/pdb |
Related | 5HLN |
Descriptor | Glycogen synthase kinase-3 beta, 4-(2-methoxyphenyl)-3,7,7-trimethyl-1,6,7,8-tetrahydro-5H-pyrazolo[3,4-b]quinolin-5-one (3 entities in total) |
Functional Keywords | protein kinase, transferase-transferase inhibitor complex, transferase/transferase inhibitor |
Biological source | Homo sapiens (Human) |
Cellular location | Cytoplasm: P49841 |
Total number of polymer chains | 2 |
Total formula weight | 95189.73 |
Authors | White, A.,Lakshminarasimhan, D.,Nadupalli, A.,Suto, R.K. (deposition date: 2016-01-15, release date: 2016-05-25, Last modification date: 2016-07-27) |
Primary citation | Wagner, F.F.,Bishop, J.A.,Gale, J.P.,Shi, X.,Walk, M.,Ketterman, J.,Patnaik, D.,Barker, D.,Walpita, D.,Campbell, A.J.,Nguyen, S.,Lewis, M.,Ross, L.,Weiwer, M.,An, W.F.,Germain, A.R.,Nag, P.P.,Metkar, S.,Kaya, T.,Dandapani, S.,Olson, D.E.,Barbe, A.L.,Lazzaro, F.,Sacher, J.R.,Cheah, J.H.,Fei, D.,Perez, J.,Munoz, B.,Palmer, M.,Stegmaier, K.,Schreiber, S.L.,Scolnick, E.,Zhang, Y.L.,Haggarty, S.J.,Holson, E.B.,Pan, J.Q. Inhibitors of Glycogen Synthase Kinase 3 with Exquisite Kinome-Wide Selectivity and Their Functional Effects. Acs Chem.Biol., 11:1952-1963, 2016 Cited by PubMed: 27128528DOI: 10.1021/acschembio.6b00306 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.45 Å) |
Structure validation
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