5HIB

EGFR kinase domain mutant "TMLR" with a pyrazolopyrimidine inhibitor

Summary for 5HIB

Entry DOI	10.2210/pdb5hib/pdb
Related	5HIC
Descriptor	Epidermal growth factor receptor, N-tert-butyl-5-{[(1-methyl-1H-pyrazol-5-yl)sulfonyl]amino}pyrazolo[1,5-a]pyrimidine-3-carboxamide (2 entities in total)
Functional Keywords	protein kinase, inhibitor, transferase-transferase inhibitor complex, transferase/transferase inhibitor
Biological source	Homo sapiens (Human)
Cellular location	Cell membrane; Single-pass type I membrane protein. Isoform 2: Secreted: P00533
Total number of polymer chains	1
Total formula weight	37926.82
Authors	Eigenbrot, C.,Yu, C. (deposition date: 2016-01-11, release date: 2016-04-06, Last modification date: 2024-03-06)
Primary citation	Foster, S.A.,Whalen, D.M.,Ozen, A.,Wongchenko, M.J.,Yin, J.,Yen, I.,Schaefer, G.,Mayfield, J.D.,Chmielecki, J.,Stephens, P.J.,Albacker, L.A.,Yan, Y.,Song, K.,Hatzivassiliou, G.,Eigenbrot, C.,Yu, C.,Shaw, A.S.,Manning, G.,Skelton, N.J.,Hymowitz, S.G.,Malek, S. Activation Mechanism of Oncogenic Deletion Mutations in BRAF, EGFR, and HER2. Cancer Cell, 29:477-493, 2016 Cited by PubMed: 26996308 DOI: 10.1016/j.ccell.2016.02.010 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.85 Å)

Structure validation