5GJE
Three-dimensional reconstruction of human LRP6 ectodomain complexed with Dkk1
Summary for 5GJE
Entry DOI | 10.2210/pdb5gje/pdb |
EMDB information | 9501 |
Descriptor | Low-density lipoprotein receptor-related protein 6, Dickkopf-related protein 1, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ... (9 entities in total) |
Functional Keywords | wnt signaling, wnt co-receptor, lrp6, glycoprotein, antagonist, dkk1, conformational change, signaling protein |
Biological source | Homo sapiens (Human) More |
Total number of polymer chains | 3 |
Total formula weight | 151666.37 |
Authors | Matoba, K.,Mihara, E.,Tamura-Kawakami, K.,Hirai, H.,Thompson, S.,Iwasaki, K.,Takagi, J. (deposition date: 2016-06-29, release date: 2017-01-18, Last modification date: 2020-07-29) |
Primary citation | Matoba, K.,Mihara, E.,Tamura-Kawakami, K.,Miyazaki, N.,Maeda, S.,Hirai, H.,Thompson, S.,Iwasaki, K.,Takagi, J. Conformational Freedom of the LRP6 Ectodomain Is Regulated by N-glycosylation and the Binding of the Wnt Antagonist Dkk1 Cell Rep, 18:32-40, 2017 Cited by PubMed: 28052259DOI: 10.1016/j.celrep.2016.12.017 PDB entries with the same primary citation |
Experimental method | ELECTRON MICROSCOPY (21 Å) |
Structure validation
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