5FHQ
Crystal structure of (WT) Rat Catechol-O-Methyltransferase in complex with AdoMet and 3,5-dinitrocatechol (DNC)
Summary for 5FHQ
Entry DOI | 10.2210/pdb5fhq/pdb |
Descriptor | Catechol O-methyltransferase, S-ADENOSYLMETHIONINE, 3,5-DINITROCATECHOL, ... (5 entities in total) |
Functional Keywords | methyltransferase regioselectivity, transferase |
Biological source | Rattus norvegicus (Norway Rat) |
Cellular location | Isoform 2: Cytoplasm. Isoform 1: Cell membrane; Single-pass type II membrane protein; Extracellular side: P22734 |
Total number of polymer chains | 1 |
Total formula weight | 24604.38 |
Authors | Levy, C. (deposition date: 2015-12-22, release date: 2016-02-03, Last modification date: 2024-01-10) |
Primary citation | Law, B.J.,Bennett, M.R.,Thompson, M.L.,Levy, C.,Shepherd, S.A.,Leys, D.,Micklefield, J. Effects of Active-Site Modification and Quaternary Structure on the Regioselectivity of Catechol-O-Methyltransferase. Angew.Chem.Int.Ed.Engl., 55:2683-2687, 2016 Cited by PubMed: 26797714DOI: 10.1002/anie.201508287 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.63 Å) |
Structure validation
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