5EOB
Crystal structure of CMET in complex with novel inhibitor
Summary for 5EOB
Entry DOI | 10.2210/pdb5eob/pdb |
Descriptor | Hepatocyte growth factor receptor, 6-[bis(fluoranyl)-[6-(4-fluorophenyl)-[1,2,4]triazolo[4,3-b][1,2,4]triazin-3-yl]methyl]quinoline (3 entities in total) |
Functional Keywords | cmet inhibitor, transferase |
Biological source | Homo sapiens (Human) |
Cellular location | Membrane; Single-pass type I membrane protein. Isoform 3: Secreted: P08581 |
Total number of polymer chains | 1 |
Total formula weight | 36425.93 |
Authors | |
Primary citation | Zhan, Z.,Peng, X.,Liu, Q.,Chen, F.,Ji, Y.,Yao, S.,Xi, Y.,Lin, Y.,Chen, T.,Xu, Y.,Ai, J.,Geng, M.,Duan, W. Discovery of 6-(difluoro(6-(4-fluorophenyl)-[1,2,4]triazolo[4,3-b][1,2,4]triazin-3-yl)methyl)quinoline as a highly potent and selective c-Met inhibitor Eur.J.Med.Chem., 116:239-251, 2016 Cited by PubMed: 27061987DOI: 10.1016/j.ejmech.2016.03.076 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.75 Å) |
Structure validation
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