5EHR
Non-receptor Protein Tyrosine Phosphatase SHP2 in Complex with Allosteric Inhibitor SHP099
Summary for 5EHR
Entry DOI | 10.2210/pdb5ehr/pdb |
Descriptor | Tyrosine-protein phosphatase non-receptor type 11, 6-(4-azanyl-4-methyl-piperidin-1-yl)-3-[2,3-bis(chloranyl)phenyl]pyrazin-2-amine, PHOSPHATE ION, ... (4 entities in total) |
Functional Keywords | phosphatase ptp inhibitor ptpn11 allosteric, hydrolase-hydrolase inhibitor complex, hydrolase/hydrolase inhibitor |
Biological source | Homo sapiens (Human) |
Cellular location | Cytoplasm: Q06124 |
Total number of polymer chains | 2 |
Total formula weight | 121944.42 |
Authors | |
Primary citation | Chen, Y.P.,LaMarche, M.J.,Chan, H.M.,Fekkes, P.,Garcia-Fortanet, J.,Acker, M.G.,Antonakos, B.,Chen, C.H.,Chen, Z.,Cooke, V.G.,Dobson, J.R.,Deng, Z.,Fei, F.,Firestone, B.,Fodor, M.,Fridrich, C.,Gao, H.,Grunenfelder, D.,Hao, H.X.,Jacob, J.,Ho, S.,Hsiao, K.,Kang, Z.B.,Karki, R.,Kato, M.,Larrow, J.,La Bonte, L.R.,Lenoir, F.,Liu, G.,Liu, S.,Majumdar, D.,Meyer, M.J.,Palermo, M.,Perez, L.,Pu, M.,Price, E.,Quinn, C.,Shakya, S.,Shultz, M.D.,Slisz, J.,Venkatesan, K.,Wang, P.,Warmuth, M.,Williams, S.,Yang, G.,Yuan, J.,Zhang, J.H.,Zhu, P.,Ramsey, T.,Keen, N.J.,Sellers, W.R.,Stams, T.,Fortin, P.D. Allosteric inhibition of SHP2 phosphatase inhibits cancers driven by receptor tyrosine kinases. Nature, 535:148-152, 2016 Cited by PubMed: 27362227DOI: 10.1038/nature18621 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.7 Å) |
Structure validation
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