5EC9

Retinoic acid receptor alpha in complex with chiral dihydrobenzofuran benzoic acid 9a and a fragment of the coactivator TIF2

Summary for 5EC9

Entry DOI	10.2210/pdb5ec9/pdb
Descriptor	Retinoic acid receptor RXR-alpha, LYS-HIS-LYS-ILE-LEU-HIS-ARG-LEU-LEU-GLN-ASP, 4-[(11S,15R)-4,4,7,7-Tetramethyl-16-oxatetracyclo[8.6.0.03,8.011,15]hexadeca-1(10),2,8-trien-11-yl]benzoic acid, ... (4 entities in total)
Functional Keywords	transcription, nuclear receptor, agonist
Biological source	Homo sapiens (Human) More
Cellular location	Nucleus : P19793
Total number of polymer chains	2
Total formula weight	25460.84
Authors	Leysen, S.,Ottmann, C.,Schafer, A.,Scheepstra, M.,Brunsveld, L.,Sunden, R.,Ma, J.N.,Burnstein, E.S.,Olsson, R. (deposition date: 2015-10-20, release date: 2016-03-09, Last modification date: 2022-08-10)
Primary citation	Sunden, H.,Schafer, A.,Scheepstra, M.,Leysen, S.,Malo, M.,Ma, J.N.,Burstein, E.S.,Ottmann, C.,Brunsveld, L.,Olsson, R. Chiral Dihydrobenzofuran Acids Show Potent Retinoid X Receptor-Nuclear Receptor Related 1 Protein Dimer Activation. J.Med.Chem., 59:1232-1238, 2016 Cited by PubMed: 26820900 DOI: 10.1021/acs.jmedchem.5b01702 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.3 Å)

Structure validation