5E0E

Crystal Structure of Cytochrome P450 2B37 from Desert Woodrat in complex with 4-(4-chlorophenyl)imidazole

Summary for 5E0E

Entry DOI	10.2210/pdb5e0e/pdb
Descriptor	Cytochrome P450 family 2 subfamily B, PROTOPORPHYRIN IX CONTAINING FE, 4-(4-CHLOROPHENYL)IMIDAZOLE, ... (4 entities in total)
Functional Keywords	cytochrome p450, cyp2b37, 4-(4-chlorophenyl)imidazole, inhibitor, oxidoreductase-oxidoreductase inhibitor complex, oxidoreductase/oxidoreductase inhibitor
Biological source	Neotoma lepida (Desert woodrat)
Total number of polymer chains	1
Total formula weight	54351.20
Authors	Shah, M.B.,Halpert, J.R.,Stout, C.D. (deposition date: 2015-09-28, release date: 2016-02-10, Last modification date: 2023-09-27)
Primary citation	Shah, M.B.,Liu, J.,Huo, L.,Zhang, Q.,Dearing, M.D.,Wilderman, P.R.,Szklarz, G.D.,Stout, C.D.,Halpert, J.R. Structure-Function Analysis of Mammalian CYP2B Enzymes Using 7-Substituted Coumarin Derivatives as Probes: Utility of Crystal Structures and Molecular Modeling in Understanding Xenobiotic Metabolism. Mol.Pharmacol., 89:435-445, 2016 Cited by PubMed: 26826176 DOI: 10.1124/mol.115.102111 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (3.4 Å)

Structure validation