5DW2

X-ray crystal structure of human BRD4(BD1) in complex with RVX297 to 1.12 A resolution

Summary for 5DW2

• Entry DOI: 10.2210/pdb5dw2/pdb
• Related: 5DW1
• Descriptor: Bromodomain-containing protein 4, 2-{3,5-dimethyl-4-[2-(pyrrolidin-1-yl)ethoxy]phenyl}-5,7-dimethoxyquinazolin-4(3H)-one, 1,2-ETHANEDIOL, ... (4 entities in total)
• Functional Keywords: bromodomain, protein binding-inhibitor complex, protein binding/inhibitor
• Biological source: Homo sapiens (Human)
• Cellular location: Nucleus: O60885
• Total number of polymer chains: 1
• Total formula weight: 16001.38

Authors

White, A.,Fontano, E.,Suto, R.K. (deposition date: 2015-09-22, release date: 2016-06-22, Last modification date: 2024-03-06)

• Primary citation: Kharenko, O.A.,Gesner, E.M.,Patel, R.G.,Norek, K.,White, A.,Fontano, E.,Suto, R.K.,Young, P.R.,McLure, K.G.,Hansen, H.C.; RVX-297- a novel BD2 selective inhibitor of BET bromodomains.; Biochem.Biophys.Res.Commun., 477:62-67, 2016; PubMed: 27282480; DOI: 10.1016/j.bbrc.2016.06.021

Experimental method

X-RAY DIFFRACTION (1.12 Å)