5DK5

Crystal structure of CRN-4-MES complex

Summary for 5DK5

• Entry DOI: 10.2210/pdb5dk5/pdb
• Descriptor: Cell death-related nuclease 4, ZINC ION, 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, ... (6 entities in total)
• Functional Keywords: deddh exonuclease, inhibitor, complex structure, dnase, rnase, hydrolase
• Biological source: Caenorhabditis elegans
• Total number of polymer chains: 2
• Total formula weight: 72175.82

Authors

Hsiao, Y.-Y.,Yuan, H.S. (deposition date: 2015-09-03, release date: 2016-08-24, Last modification date: 2023-11-08)

• Primary citation: Huang, K.-W.,Hsu, K.-C.,Chu, L.-Y.,Yang, J.-M.,Yuan, H.S.,Hsiao, Y.-Y.; Identification of Inhibitors for the DEDDh Family of Exonucleases and a Unique Inhibition Mechanism by Crystal Structure Analysis of CRN-4 Bound with 2-Morpholin-4-ylethanesulfonate (MES); J.Med.Chem., 59:8019-8029, 2016; PubMed: 27529560; DOI: 10.1021/acs.jmedchem.6b00794

Experimental method

X-RAY DIFFRACTION (2.1 Å)