5D7X
Crystal structure of the human BRPF1 bromodomain in complex with XZ08
Summary for 5D7X
Entry DOI | 10.2210/pdb5d7x/pdb |
Descriptor | Peregrin, NITRATE ION, 4-(1-acetyl-1H-indol-3-yl)-5-methyl-1,2-dihydro-3H-pyrazol-3-one, ... (4 entities in total) |
Functional Keywords | bromodomain and phd finger-containing protein 1(brpf1), monocytic leukemia zinc-finger (moz), inhibitor, dna binding protein |
Biological source | Homo sapiens (Human) |
Cellular location | Nucleus : P55201 |
Total number of polymer chains | 1 |
Total formula weight | 14020.98 |
Authors | Zhu, J.,Caflisch, A. (deposition date: 2015-08-14, release date: 2016-05-25, Last modification date: 2024-01-10) |
Primary citation | Unzue, A.,Zhao, H.,Lolli, G.,Dong, J.,Zhu, J.,Zechner, M.,Dolbois, A.,Caflisch, A.,Nevado, C. The "Gatekeeper" Residue Influences the Mode of Binding of Acetyl Indoles to Bromodomains. J.Med.Chem., 59:3087-3097, 2016 Cited by PubMed: 26982797DOI: 10.1021/acs.jmedchem.5b01757 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.35 Å) |
Structure validation
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