5CEI
Crystal structure of CDK8:Cyclin C complex with compound 22
Summary for 5CEI
Entry DOI | 10.2210/pdb5cei/pdb |
Related | 4G6L |
Descriptor | Cyclin-dependent kinase 8, Cyclin-C, 1,2-ETHANEDIOL, ... (6 entities in total) |
Functional Keywords | kinase, inhibitor, cdk8, cyclin dependent kinase, cyclin, transcription-transferase-inhibitor complex, transcription/transferase/inhibitor |
Biological source | Homo sapiens (Human) More |
Cellular location | Nucleus : P49336 P24863 |
Total number of polymer chains | 2 |
Total formula weight | 82044.96 |
Authors | Kiefer, J.R.,Schneider, E.V.,Maskos, K.,Koehler, M.F.T. (deposition date: 2015-07-06, release date: 2016-02-10, Last modification date: 2024-03-06) |
Primary citation | Koehler, M.F.,Bergeron, P.,Blackwood, E.M.,Bowman, K.,Clark, K.R.,Firestein, R.,Kiefer, J.R.,Maskos, K.,McCleland, M.L.,Orren, L.,Salphati, L.,Schmidt, S.,Schneider, E.V.,Wu, J.,Beresini, M.H. Development of a Potent, Specific CDK8 Kinase Inhibitor Which Phenocopies CDK8/19 Knockout Cells. Acs Med.Chem.Lett., 7:223-228, 2016 Cited by PubMed: 26985305DOI: 10.1021/acsmedchemlett.5b00278 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.24 Å) |
Structure validation
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