5C8I
Joint X-ray/neutron structure of Human Carbonic Anhydrase II in complex with Methazolamide
Summary for 5C8I
Entry DOI | 10.2210/pdb5c8i/pdb |
Related | 4G0C |
Descriptor | Carbonic anhydrase 2, ZINC ION, N-(3-methyl-5-sulfamoyl-1,3,4-thiadiazol-2(3H)-ylidene)acetamide, ... (4 entities in total) |
Functional Keywords | methazolamide, acetazolamide, water displacement, lyase |
Biological source | Homo sapiens (Human) |
Total number of polymer chains | 1 |
Total formula weight | 29590.74 |
Authors | Aggarwal, M.,Kovalevsky, A.Y.,Fisher, S.Z.,McKenna, R. (deposition date: 2015-06-25, release date: 2016-07-20, Last modification date: 2024-03-06) |
Primary citation | Aggarwal, M.,Kovalevsky, A.Y.,Velazquez, H.,Fisher, S.Z.,Smith, J.C.,McKenna, R. Neutron structure of human carbonic anhydrase II in complex with methazolamide: mapping the solvent and hydrogen-bonding patterns of an effective clinical drug. IUCrJ, 3:319-325, 2016 Cited by PubMed: 28461893DOI: 10.1107/S2052252516010514 PDB entries with the same primary citation |
Experimental method | NEUTRON DIFFRACTION (2.2 Å) X-RAY DIFFRACTION (1.56 Å) |
Structure validation
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