5APH
Ligand complex of RORg LBD
Summary for 5APH
Entry DOI | 10.2210/pdb5aph/pdb |
Related | 5APJ 5APK |
Descriptor | NUCLEAR RECEPTOR ROR-GAMMA, NUCLEAR RECEPTOR COACTIVATOR 2, N-(2-FLUOROPHENYL)-4-[(4-FLUOROPHENYL)SULFONYL]-2,3,4,5-TETRAHYDRO-1,4-BENZOXAZEPIN-6-AMINE, ... (5 entities in total) |
Functional Keywords | transcription, rorg ligand, rorg agonist, structure-based design |
Biological source | HOMO SAPIENS (HUMAN) More |
Cellular location | Nucleus : P51449 E7EWM1 |
Total number of polymer chains | 2 |
Total formula weight | 32888.76 |
Authors | Xue, Y.,Aagaard, A.,Narjes, F. (deposition date: 2015-09-16, release date: 2015-11-25, Last modification date: 2024-01-10) |
Primary citation | Olsson, R.I.,Xue, Y.,von Berg, S.,Aagaard, A.,McPheat, J.,Hansson, E.L.,Bernstrom, J.,Hansson, P.,Jirholt, J.,Grindebacke, H.,Leffler, A.,Chen, R.,Xiong, Y.,Ge, H.,Hansson, T.G.,Narjes, F. Benzoxazepines Achieve Potent Suppression of IL-17 Release in Human T-Helper 17 (TH 17) Cells through an Induced-Fit Binding Mode to the Nuclear Receptor ROR gamma. ChemMedChem, 11:207-216, 2016 Cited by PubMed: 26553345DOI: 10.1002/cmdc.201500432 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.54 Å) |
Structure validation
Download full validation report