5A3X
DYRK1A in complex with hydroxy benzothiazole fragment
Summary for 5A3X
| Entry DOI | 10.2210/pdb5a3x/pdb |
| Related | 5A4E 5A4L |
| Descriptor | DUAL SPECIFICITY TYROSINE-PHOSPHORYLATION-REGULATED KINASE 1A, N-(5-oxidanyl-1,3-benzothiazol-2-yl)ethanamide (3 entities in total) |
| Functional Keywords | transferase, protein kinase |
| Biological source | HOMO SAPIENS (HUMAN) |
| Total number of polymer chains | 4 |
| Total formula weight | 171448.92 |
| Authors | Rothweiler, U. (deposition date: 2015-06-03, release date: 2016-06-29, Last modification date: 2019-02-06) |
| Primary citation | Rothweiler, U.,Stensen, W.,Brandsdal, B.O.,Isaksson, J.,Leeson, F.A.,Eugh, R.A.,Mjoen Svendsen, J.S. Probing the ATP-Binding Pocket of Protein Kinase Dyrk1A with Benzothiazole Fragment Molecules J.Med.Chem., 59:9814-, 2016 Cited by PubMed: 27736065DOI: 10.1021/ACS.JMEDCHEM.6B01086 PDB entries with the same primary citation |
| Experimental method | X-RAY DIFFRACTION (2.26 Å) |
Structure validation
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