5KZV
Crystal structure of the xenopus Smoothened cysteine-rich domain (CRD) in complex with 20(S)-hydroxycholesterol
Summary for 5KZV
Entry DOI | 10.2210/pdb5kzv/pdb |
Descriptor | Smoothened, (3alpha,8alpha)-cholest-5-ene-3,20-diol (3 entities in total) |
Functional Keywords | hedgehog signaling, gpcr, cysteine-rich domain, sterol, signaling protein |
Biological source | Xenopus laevis (African clawed frog) |
Total number of polymer chains | 1 |
Total formula weight | 14393.71 |
Authors | |
Primary citation | Huang, P.,Nedelcu, D.,Watanabe, M.,Jao, C.,Kim, Y.,Liu, J.,Salic, A. Cellular Cholesterol Directly Activates Smoothened in Hedgehog Signaling. Cell, 166:1176-1187.e14, 2016 Cited by PubMed: 27545348DOI: 10.1016/j.cell.2016.08.003 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.616 Å) |
Structure validation
Download full validation report