5I88
BRD4 in complex with Cpd4 ((E)-3-(6-(but-2-en-1-yl)-7-oxo-6,7-dihydro-1H-pyrrolo[2,3-c]pyridin-4-yl)-N,N-dimethylbenzamide)
Summary for 5I88
Entry DOI | 10.2210/pdb5i88/pdb |
Related | 5I7Y |
Descriptor | Bromodomain-containing protein 4, TRIETHYLENE GLYCOL, 1,2-ETHANEDIOL, ... (7 entities in total) |
Functional Keywords | brd4, bromodomain, epigenetics, structure-based design, transcription |
Biological source | Homo sapiens (Human) |
Cellular location | Nucleus: O60885 |
Total number of polymer chains | 1 |
Total formula weight | 15720.11 |
Authors | Murray, J.M. (deposition date: 2016-02-18, release date: 2016-10-12, Last modification date: 2024-03-06) |
Primary citation | Crawford, T.D.,Tsui, V.,Flynn, E.M.,Wang, S.,Taylor, A.M.,Cote, A.,Audia, J.E.,Beresini, M.H.,Burdick, D.J.,Cummings, R.,Dakin, L.A.,Duplessis, M.,Good, A.C.,Hewitt, M.C.,Huang, H.R.,Jayaram, H.,Kiefer, J.R.,Jiang, Y.,Murray, J.,Nasveschuk, C.G.,Pardo, E.,Poy, F.,Romero, F.A.,Tang, Y.,Wang, J.,Xu, Z.,Zawadzke, L.E.,Zhu, X.,Albrecht, B.K.,Magnuson, S.R.,Bellon, S.,Cochran, A.G. Diving into the Water: Inducible Binding Conformations for BRD4, TAF1(2), BRD9, and CECR2 Bromodomains. J.Med.Chem., 59:5391-5402, 2016 Cited by PubMed: 27219867DOI: 10.1021/acs.jmedchem.6b00264 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.4 Å) |
Structure validation
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