5B5B

Crystal structure of VDR-LBD complexed with 2-methylidene-26,27-diphenyl-19-nor-1,25-dihydroxyvitamin D3

Summary for 5B5B

Entry DOI	10.2210/pdb5b5b/pdb
Descriptor	Vitamin D3 receptor, Mediator of RNA polymerase II transcription subunit 1, (1R,3R)-5-[(2E)-2-[(1R,3aS,7aR)-7a-methyl-1-[(2R)-6-oxidanyl-7-phenyl-6-(phenylmethyl)heptan-2-yl]-2,3,3a,5,6,7-hexahydro-1H-inden-4-ylidene]ethylidene]-2-methylidene-cyclohexane-1,3-diol, ... (4 entities in total)
Functional Keywords	transcription, vitamin d3, vdr, vdre, rxr, co-factors, antagonist
Biological source	Rattus norvegicus (Rat) More
Total number of polymer chains	4
Total formula weight	65469.53
Authors	Kato, A.,Itoh, T.,Yamamoto, K. (deposition date: 2016-05-02, release date: 2016-06-29, Last modification date: 2024-03-20)
Primary citation	Kato, A.,Itoh, T.,Anami, Y.,Egawa, D.,Yamamoto, K. Helix12-Stabilization Antagonist of Vitamin D Receptor Bioconjug.Chem., 27:1750-1761, 2016 Cited by PubMed: 27294600 DOI: 10.1021/acs.bioconjchem.6b00246 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2 Å)

Structure validation