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4ZGK

Structure of Mdm2 with low molecular weight inhibitor.

Summary for 4ZGK
Entry DOI10.2210/pdb4zgk/pdb
Related4ZFI
DescriptorE3 ubiquitin-protein ligase Mdm2, (5R)-3,5-bis(4-chlorobenzyl)-4-(6-chloro-1H-indol-3-yl)-5-hydroxyfuran-2(5H)-one (3 entities in total)
Functional Keywordsp53-mdm2/mdmx interaction, inhibitor, ligase
Biological sourceHomo sapiens (Human)
Cellular locationNucleus, nucleoplasm: Q00987
Total number of polymer chains2
Total formula weight24054.55
Authors
Twarda-Clapa, A.,Zak, K.M.,Wrona, E.M.,Grudnik, P.,Dubin, G.,Holak, T.A. (deposition date: 2015-04-23, release date: 2016-10-19, Last modification date: 2024-01-10)
Primary citationSurmiak, E.,Twarda-Clapa, A.,Zak, K.M.,Musielak, B.,Tomala, M.D.,Kubica, K.,Grudnik, P.,Madej, M.,Jablonski, M.,Potempa, J.,Kalinowska-Tluscik, J.,Domling, A.,Dubin, G.,Holak, T.A.
A Unique Mdm2-Binding Mode of the 3-Pyrrolin-2-one- and 2-Furanone-Based Antagonists of the p53-Mdm2 Interaction.
ACS Chem. Biol., 11:3310-3318, 2016
Cited by
PubMed: 27709883
DOI: 10.1021/acschembio.6b00596
PDB entries with the same primary citation
Experimental method
X-RAY DIFFRACTION (2 Å)
Structure validation

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