4Z7Q

Integrin alphaIIbbeta3 in complex with AGDV-NH2 peptide

Summary for 4Z7Q

• Entry DOI: 10.2210/pdb4z7q/pdb
• Related: 4Z7N 4Z7O 4Z7S
• Descriptor: Integrin alpha-IIb, SULFATE ION, GLYCEROL, ... (16 entities in total)
• Functional Keywords: cell adhesion, platelet aggregation, membrane protein-immune system complex, membrane protein/immune system
• Biological source: Homo sapiens (Human); More
• Cellular location: Membrane; Single-pass type I membrane protein: P08514; Cell membrane ; Single- pass type I membrane protein : P05106
• Total number of polymer chains: 10
• Total formula weight: 301400.53

Authors

Lin, F.-Y.,Zhu, J.,Springer, T.A. (deposition date: 2015-04-07, release date: 2015-12-16, Last modification date: 2020-07-29)

• Primary citation: Lin, F.Y.,Zhu, J.,Eng, E.T.,Hudson, N.E.,Springer, T.A.; beta-Subunit Binding Is Sufficient for Ligands to Open the Integrin alpha IIb beta 3 Headpiece.; J.Biol.Chem., 291:4537-4546, 2016; PubMed: 26631735; DOI: 10.1074/jbc.M115.705624

Experimental method

X-RAY DIFFRACTION (2.7 Å)