4XZ0

ZAP-70-tSH2:compound-A complex

Summary for 4XZ0

Entry DOI	10.2210/pdb4xz0/pdb
Related	4XZ1
Descriptor	Tyrosine-protein kinase ZAP-70, 1-(3-{5-[(3-chlorobenzyl)sulfonyl]-1H-tetrazol-1-yl}phenyl)ethanone, SULFATE ION, ... (4 entities in total)
Functional Keywords	tyrosine kinase, cysteine adduct, transferase-transferase inhibitor complex, transferase/transferase inhibitor
Biological source	Homo sapiens (Human)
Total number of polymer chains	1
Total formula weight	30100.76
Authors	Barros, T.,Kuriyan, J.,Visperas, P.R.,Winger, J.A. (deposition date: 2015-02-03, release date: 2015-06-17, Last modification date: 2023-09-27)
Primary citation	Visperas, P.R.,Winger, J.A.,Horton, T.M.,Shah, N.H.,Aum, D.J.,Tao, A.,Barros, T.,Yan, Q.,Wilson, C.G.,Arkin, M.R.,Weiss, A.,Kuriyan, J. Modification by covalent reaction or oxidation of cysteine residues in the tandem-SH2 domains of ZAP-70 and Syk can block phosphopeptide binding. Biochem. J., 465:149-161, 2015 Cited by PubMed: 25287889 DOI: 10.1042/BJ20140793 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2 Å)

Structure validation