4XEY

Crystal structure of an SH2-kinase domain construct of c-Abl tyrosine kinase

Summary for 4XEY

Entry DOI	10.2210/pdb4xey/pdb
Descriptor	Tyrosine-protein kinase ABL1, N-(2-CHLORO-6-METHYLPHENYL)-2-({6-[4-(2-HYDROXYETHYL)PIPERAZIN-1-YL]-2-METHYLPYRIMIDIN-4-YL}AMINO)-1,3-THIAZOLE-5-CARBOXAMIDE (2 entities in total)
Functional Keywords	tyrosine kinase, kinase domain, sh2 domain, dasatinib, transferase-transferase inhibitor complex, transferase/transferase inhibitor
Biological source	Homo sapiens (Human)
Cellular location	Cytoplasm, cytoskeleton. Isoform IB: Nucleus membrane; Lipid-anchor: P00519
Total number of polymer chains	2
Total formula weight	94696.01
Authors	Lorenz, S.,Deng, P.,Kuriyan, J. (deposition date: 2014-12-25, release date: 2015-04-01, Last modification date: 2023-09-27)
Primary citation	Lorenz, S.,Deng, P.,Hantschel, O.,Superti-Furga, G.,Kuriyan, J. Crystal structure of an SH2-kinase construct of c-Abl and effect of the SH2 domain on kinase activity. Biochem.J., 468:283-291, 2015 Cited by PubMed: 25779001 DOI: 10.1042/BJ20141492 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.891 Å)

Structure validation