4XCN

Crystal structure of human 4E10 Fab in complex with phosphatidic acid (06:0 PA); 2.9 A resolution

Summary for 4XCN

• Entry DOI: 10.2210/pdb4xcn/pdb
• Related: 4XAW 4XBE 4XBG 4XBP 4XC1 4XC3 4XCC 4XCE 4XCF 4XCY
• Descriptor: 4E10 Fab light chain, 4E10 Fab heavy chain, UNKNOWN LIGAND, ... (7 entities in total)
• Functional Keywords: human anti gp41 hiv-1 4e10 fab, membrane lipids, phosphatidic acid, immune system
• Biological source: Homo sapiens; More
• Total number of polymer chains: 12
• Total formula weight: 286570.33

Authors

Irimia, A.,Stanfield, R.L.,Wilson, I.A. (deposition date: 2014-12-18, release date: 2016-02-03, Last modification date: 2023-09-27)

• Primary citation: Irimia, A.,Sarkar, A.,Stanfield, R.L.,Wilson, I.A.; Crystallographic Identification of Lipid as an Integral Component of the Epitope of HIV Broadly Neutralizing Antibody 4E10.; Immunity, 44:21-31, 2016; PubMed: 26777395; DOI: 10.1016/j.immuni.2015.12.001

Experimental method

X-RAY DIFFRACTION (2.9 Å)