4X2N
Selection of fragments for kinase inhibitor design: decoration is key
Summary for 4X2N
| Entry DOI | 10.2210/pdb4x2n/pdb |
| Descriptor | TGF-beta receptor type-1, SULFATE ION (3 entities in total) |
| Functional Keywords | transferase, protein kinase, inhibitor complex |
| Biological source | Homo sapiens (Human) |
| Cellular location | Cell membrane; Single-pass type I membrane protein: P36897 |
| Total number of polymer chains | 1 |
| Total formula weight | 34978.21 |
| Authors | Czodrowski, P.,Hoelzemann, G.,Barnickel, G.,Greiner, H.,Musil, D. (deposition date: 2014-11-26, release date: 2014-12-24, Last modification date: 2015-01-21) |
| Primary citation | Czodrowski, P.,Holzemann, G.,Barnickel, G.,Greiner, H.,Musil, D. Selection of fragments for kinase inhibitor design: decoration is key. J.Med.Chem., 58:457-465, 2015 Cited by PubMed: 25437144DOI: 10.1021/jm501597j PDB entries with the same primary citation |
| Experimental method | X-RAY DIFFRACTION (1.8 Å) |
Structure validation
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