4WQP
Crystal structure of RORc in complex with a benzyl sulfonamide inverse agonist
Summary for 4WQP
Entry DOI | 10.2210/pdb4wqp/pdb |
Descriptor | Nuclear receptor ROR-gamma, VAL-GLU-ARG-LEU-GLN-ILE-PHE-GLN-HIS-LEU-HIS-PRO-ILE, N-[4-(4-acetylpiperazin-1-yl)benzyl]-N-(2-methylpropyl)-1-phenylmethanesulfonamide, ... (5 entities in total) |
Functional Keywords | nuclear receptor ligand binding domain, transcription |
Biological source | Homo sapiens (Human) More |
Cellular location | Nucleus : P51449 |
Total number of polymer chains | 3 |
Total formula weight | 64419.26 |
Authors | Boenig, G.,Hymowitz, S.G. (deposition date: 2014-10-22, release date: 2015-01-14, Last modification date: 2023-12-27) |
Primary citation | Rene, O.,Fauber, B.P.,de Leon Boenig, G.,Burton, B.,Eidenschenk, C.,Everett, C.,Gobbi, A.,Hymowitz, S.G.,Johnson, A.R.,Kiefer, J.R.,Liimatta, M.,Lockey, P.,Norman, M.,Ouyang, W.,Wallweber, H.A.,Wong, H. Minor Structural Change to Tertiary Sulfonamide RORc Ligands Led to Opposite Mechanisms of Action. Acs Med.Chem.Lett., 6:276-281, 2015 Cited by PubMed: 25815138DOI: 10.1021/ml500420y PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.99 Å) |
Structure validation
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