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4R3C

Crystal structure of p38 alpha MAP kinase in complex with a novel isoform selective drug candidate

Summary for 4R3C
Entry DOI10.2210/pdb4r3c/pdb
Related4EWQ 4F9W 4F9Y
DescriptorMitogen-activated protein kinase 14, 4-[3-(4-FLUOROPHENYL)-1H-PYRAZOL-4-YL]PYRIDINE, 6-(4-methylpiperazin-1-yl)-3-(naphthalen-2-yl)-4-(pyridin-4-yl)pyridazine, ... (5 entities in total)
Functional Keywordsserine/threonine-protein kinase, protein kinase domain, transferase, atp binding, phosphorylation, cytosol, transferase-transferase inhibitor complex, transferase/transferase inhibitor
Biological sourceHomo sapiens (human)
Cellular locationCytoplasm : Q16539
Total number of polymer chains1
Total formula weight45069.67
Authors
Grum-Tokars, V.L.,Minasov, G.,Roy, S.M.,Anderson, W.F.,Watterson, D.M. (deposition date: 2014-08-14, release date: 2015-02-25, Last modification date: 2017-11-22)
Primary citationRoy, S.M.,Grum-Tokars, V.L.,Schavocky, J.P.,Saeed, F.,Staniszewski, A.,Teich, A.F.,Arancio, O.,Bachstetter, A.D.,Webster, S.J.,Van Eldik, L.J.,Minasov, G.,Anderson, W.F.,Pelletier, J.C.,Watterson, D.M.
Targeting human central nervous system protein kinases: An isoform selective p38 alpha MAPK inhibitor that attenuates disease progression in Alzheimer's disease mouse models.
ACS Chem Neurosci, 6:666-680, 2015
Cited by
PubMed: 25676389
DOI: 10.1021/acschemneuro.5b00002
PDB entries with the same primary citation
Experimental method
X-RAY DIFFRACTION (2.06 Å)
Structure validation

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