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4PV0

Crystal structure of spleen tyrosine kinase (Syk) in complex with an imidazopyrazine inhibitor

Summary for 4PV0
Entry DOI10.2210/pdb4pv0/pdb
Related4PUZ
DescriptorTyrosine-protein kinase SYK, 4-[(3-{8-[(3,4-dimethoxyphenyl)amino]imidazo[1,2-a]pyrazin-6-yl}benzoyl)amino]benzoic acid, CHLORIDE ION, ... (4 entities in total)
Functional Keywordssyk, spleen tyrosine kinase, kinase inhibitor, protein kinase, transferase-transferase inhibitor complex, transferase/transferase inhibitor
Biological sourceHomo sapiens (human)
Total number of polymer chains1
Total formula weight32542.50
Authors
Lansdon, E.B.,Mitchell, S.A. (deposition date: 2014-03-14, release date: 2014-05-21, Last modification date: 2023-09-20)
Primary citationCurrie, K.S.,Kropf, J.E.,Lee, T.,Blomgren, P.,Xu, J.,Zhao, Z.,Gallion, S.,Whitney, J.A.,Maclin, D.,Lansdon, E.B.,Maciejewski, P.,Rossi, A.M.,Rong, H.,Macaluso, J.,Barbosa, J.,Di Paolo, J.A.,Mitchell, S.A.
Discovery of GS-9973, a Selective and Orally Efficacious Inhibitor of Spleen Tyrosine Kinase.
J.Med.Chem., 57:3856-3873, 2014
Cited by
PubMed: 24779514
DOI: 10.1021/jm500228a
PDB entries with the same primary citation
Experimental method
X-RAY DIFFRACTION (2 Å)
Structure validation

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