Loading
PDBj
MenuPDBj@FacebookPDBj@TwitterPDBj@YouTubewwPDB FoundationwwPDB
RCSB PDBPDBeBMRBAdv. SearchSearch help

4PTE

Structure of a carvoxamide compound (15) (N-[4-(ISOQUINOLIN-7-YL)PYRIDIN-2-YL]CYCLOPROPANECARBOXAMIDE) to GSK3b

Summary for 4PTE
Entry DOI10.2210/pdb4pte/pdb
Related4PTC 4PTG
DescriptorGlycogen synthase kinase-3 beta, N-[4-(isoquinolin-7-yl)pyridin-2-yl]cyclopropanecarboxamide (3 entities in total)
Functional Keywordsserine/threonine kinase, transferase-transferase inhibitor complex, transferase/transferase inhibitor
Biological sourceHomo sapiens (human)
Cellular locationCytoplasm: P49841
Total number of polymer chains2
Total formula weight99168.32
Authors
Lewis, H.A.,Sivaprakasam, P.,Kish, K.,Pokross, M.,Dubowchik, G.M. (deposition date: 2014-03-10, release date: 2015-04-08, Last modification date: 2024-02-28)
Primary citationSivaprakasam, P.,Han, X.,Civiello, R.L.,Jacutin-Porte, S.,Kish, K.,Pokross, M.,Lewis, H.A.,Ahmed, N.,Szapiel, N.,Newitt, J.A.,Baldwin, E.T.,Xiao, H.,Krause, C.M.,Park, H.,Nophsker, M.,Lippy, J.S.,Burton, C.R.,Langley, D.R.,Macor, J.E.,Dubowchik, G.M.
Discovery of new acylaminopyridines as GSK-3 inhibitors by a structure guided in-depth exploration of chemical space around a pyrrolopyridinone core.
Bioorg.Med.Chem.Lett., 25:1856-1863, 2015
Cited by
PubMed: 25845281
DOI: 10.1016/j.bmcl.2015.03.046
PDB entries with the same primary citation
Experimental method
X-RAY DIFFRACTION (2.033 Å)
Structure validation

217705

PDB entries from 2024-03-27

PDB statisticsPDBj update infoContact PDBjnumon