4P0C

Crystal Structure of NHERF2 PDZ1 Domain in Complex with LPA2

Summary for 4P0C

Entry DOI	10.2210/pdb4p0c/pdb
Descriptor	Na(+)/H(+) exchange regulatory cofactor NHE-RF2/Lysophosphatidic acid receptor 2 chimeric protein, THIOCYANATE ION, CHLORIDE ION, ... (4 entities in total)
Functional Keywords	pdz, protein-protein interaction, protein binding
Biological source	Homo sapiens (Human) More
Cellular location	Cell surface : Q9HBW0
Total number of polymer chains	1
Total formula weight	9930.15
Authors	Holcomb, J.,Jiang, Y.,Lu, G.,Trescott, L.,Brunzelle, J.,Sirinupong, N.,Li, C.,Naren, A.,Yang, Z. (deposition date: 2014-02-20, release date: 2014-05-21, Last modification date: 2024-03-27)
Primary citation	Holcomb, J.,Jiang, Y.,Lu, G.,Trescott, L.,Brunzelle, J.,Sirinupong, N.,Li, C.,Naren, A.P.,Yang, Z. Structural insights into PDZ-mediated interaction of NHERF2 and LPA2, a cellular event implicated in CFTR channel regulation. Biochem.Biophys.Res.Commun., 446:399-403, 2014 Cited by PubMed: 24613836 DOI: 10.1016/j.bbrc.2014.02.128 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.339 Å)

Structure validation