4O1V

SPOP Promotes Tumorigenesis by Acting as a Key Regulatory Hub in Kidney Cancer

Summary for 4O1V

Entry DOI	10.2210/pdb4o1v/pdb
Descriptor	Speckle-type POZ protein, Phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN (3 entities in total)
Functional Keywords	ubl conjugation pathway, ligase, ubiquitin, e3, spop, math, pten, protein binding
Biological source	Homo sapiens (human) More
Cellular location	Nucleus: O43791 Cytoplasm: P60484
Total number of polymer chains	2
Total formula weight	18019.44
Authors	Calabrese, M.F.,Watson, E.R.,Schulman, B.A. (deposition date: 2013-12-16, release date: 2014-04-30, Last modification date: 2023-09-20)
Primary citation	Li, G.,Ci, W.,Karmakar, S.,Chen, K.,Dhar, R.,Fan, Z.,Guo, Z.,Zhang, J.,Ke, Y.,Wang, L.,Zhuang, M.,Hu, S.,Li, X.,Zhou, L.,Li, X.,Calabrese, M.F.,Watson, E.R.,Prasad, S.M.,Rinker-Schaeffer, C.,Eggener, S.E.,Stricker, T.,Tian, Y.,Schulman, B.A.,Liu, J.,White, K.P. SPOP Promotes Tumorigenesis by Acting as a Key Regulatory Hub in Kidney Cancer. Cancer Cell, 25:455-468, 2014 Cited by PubMed: 24656772 DOI: 10.1016/j.ccr.2014.02.007 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2 Å)

Structure validation