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4MEN

Crystal Structure of the first bromodomain of human BRD4 in complex with a 5-methyl-triazolopyrimidine ligand

Summary for 4MEN
Entry DOI10.2210/pdb4men/pdb
Related4MEO 4MEP 4MEQ
DescriptorBromodomain-containing protein 4, 1,2-ETHANEDIOL, N,5-dimethyl-N-(4-methylbenzyl)[1,2,4]triazolo[1,5-a]pyrimidin-7-amine, ... (4 entities in total)
Functional Keywordsbrd4, cap, hunk1, mcap, mitotic chromosome associated protein, brd, small molecule inhibitor, structural genomics consortium, sgc, transcription-transcription inhibitor complex, transcription/transcription inhibitor
Biological sourceHomo sapiens (human)
Cellular locationNucleus: O60885
Total number of polymer chains1
Total formula weight15428.78
Authors
Primary citationVidler, L.R.,Filippakopoulos, P.,Fedorov, O.,Picaud, S.,Martin, S.,Tomsett, M.,Woodward, H.,Brown, N.,Knapp, S.,Hoelder, S.
Discovery of Novel Small-Molecule Inhibitors of BRD4 Using Structure-Based Virtual Screening.
J.Med.Chem., 56:8073-8088, 2013
Cited by
PubMed: 24090311
DOI: 10.1021/jm4011302
PDB entries with the same primary citation
Experimental method
X-RAY DIFFRACTION (1.81 Å)
Structure validation

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