4M1C

Crystal Structure Analysis of Fab-Bound Human Insulin Degrading Enzyme (IDE) in Complex with Amyloid-Beta (1-40)

Summary for 4M1C

• Entry DOI: 10.2210/pdb4m1c/pdb
• Related: 4IOF
• Descriptor: Insulin-degrading enzyme, Fab-bound IDE, heavy chain, Fab-bound IDE, light chain, ... (5 entities in total)
• Functional Keywords: hydrolase, zinc metalloprotease
• Biological source: Homo sapiens (human); More
• Cellular location: Cytoplasm: P14735; Membrane; Single-pass type I membrane protein: P05067
• Total number of polymer chains: 8
• Total formula weight: 346291.21

Authors

McCord, L.M.,Liang, W.,Farcasanu, M.,Scherpelz, K.,Meredith, S.C.,Koide, S.,Tang, W.J. (deposition date: 2013-08-02, release date: 2014-08-06, Last modification date: 2023-09-20)

• Primary citation: McCord, L.A.,Liang, W.,Farcasanu, M.,Scherpelz, K.,Meredith, S.C.,Koide, S.,Tang, W.J.; Crystal Structure Analysis of Fab-Bound Human Insulin Degrading Enzyme (IDE) in Complex with Amyloid-Beta (1-40); To be Published,

Experimental method

X-RAY DIFFRACTION (3.5007 Å)