4LXZ

Structure of Human HDAC2 in complex with SAHA (vorinostat)

Summary for 4LXZ

• Entry DOI: 10.2210/pdb4lxz/pdb
• Related: 4LY1
• Descriptor: Histone deacetylase 2, ZINC ION, CALCIUM ION, ... (8 entities in total)
• Functional Keywords: deacetylase, histone, hydrolase-hydrolase inhibitor complex, hydrolase/hydrolase inhibitor
• Biological source: Homo sapiens (human)
• Cellular location: Nucleus: Q92769
• Total number of polymer chains: 3
• Total formula weight: 130041.19

Authors

Fong, R.,Lupardus, P.J. (deposition date: 2013-07-30, release date: 2013-08-21, Last modification date: 2023-09-20)

• Primary citation: Lauffer, B.E.,Mintzer, R.,Fong, R.,Mukund, S.,Tam, C.,Zilberleyb, I.,Flicke, B.,Ritscher, A.,Fedorowicz, G.,Vallero, R.,Ortwine, D.F.,Gunzner, J.,Modrusan, Z.,Neumann, L.,Koth, C.M.,Lupardus, P.J.,Kaminker, J.S.,Heise, C.E.,Steiner, P.; Histone Deacetylase (HDAC) Inhibitor Kinetic Rate Constants Correlate with Cellular Histone Acetylation but Not Transcription and Cell Viability.; J.Biol.Chem., 288:26926-26943, 2013; PubMed: 23897821; DOI: 10.1074/jbc.M113.490706

Experimental method

X-RAY DIFFRACTION (1.85 Å)